DoctorsAmir H. Kashani, MD, PhD

Amir H. Kashani, MD, PhD

Title: Assistant Professor of Clinical Ophthalmology

Department: Ophthalmology

Clinical Specialty: Vitreoretinal Surgery and Retina Disease

Treatment Expertise: Complicated retinal detachment repair, Recurrent retinal detachment repair, Macular degeneration, Diabetic retinopathy, Macular pucker, Retinal vein occlusions, Hypertension related eye disease

Certification: American Board of Ophthalmology

Language: English, Farsi

Location: Los Angeles and Pasadena

Biography and Education

Biography

Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed his ophthalmology residency at the USC Roski Eye Institute and fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. He was awarded both the Heed and Michel’s Fellowships (National Honors) during his training. Dr. Kashani is an NIH funded clinician-scientist who is studying the role of ischemia and hypoxia in the pathophysiology of retinal vascular diseases like diabetic retinopathy. Dr. Kashani also treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

Dr. Kashani was recently a guest speaker at the Braille Institute in Los Angeles. For a photo gallery of this community conference, click here. For video coverage of the community conference, click here.

Moreover, Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled “Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies.”

Research Interests:

In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy and retinal venous occlusion. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. In recognition of his cutting edge research Dr. Kashani has been recognized internatioinally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50 “rising stars” world-wide in the field of ophthalmology by The Ophthalmologist.

Education

  • MD, Johns Hopkins School of Medicine, 2006
  • PhD, Johns Hopkins School of Medicine, 2006

Internship

  • Johns Hopkins Hospital, Internal Medicine, 2006-2007

Residency

  • LAC+USC Medical Center, Ophthalmology, 2007-2010

Fellowship

  • Associated Retinal Consultants, Vitreoretinal Surgery, 2011-2013

Textbook

OCT and OCT Angiography

Accomplishments

Professional society memberships

  • American Academy of Ophthalmology, AAO
  • Association for Research in Vision and Ophthalmology, ARVO
  • American Society of Retina Specialists, ASRS
  • American Academy for the Advancement of Science, AAAS
  • Society of Heed Scholars
  • F1000 Associate Faculty, Member/Contributor
  • American Board of Ophthalmology, Fellow

Awards

  • Medical Student Research Fellowship, Johns Hopkins School of Medicine, 2000
  • ARVO Foundation for Research/Retina Research Foundation Grant 2006
  • Medical Scientist Training Program Fellowship (MSTP), 1999-2006
  • ARVO Research Travel Grant, 2007
  • Department of Ophthalmology, USC, Resident Research Award, 2008
  • Association for Research in Vision and Ophthalmology, 2009
  • Henry and Lilian Nesburn Award, 2009
  • Heed Resident Research Symposium (Rank #4)
  • Ron G. Michel’s Fellowship, 2012
  • Heed Ophthalmic Foundation Fellow (Society of Heed Scholars), 2012
  • Nominated to 150 leading innovators in medical and surgical retina by Ocular Surgery News, 2016
  • Nominated to The Ophthalmologists Rising Stars Power List of Ophthalmologists in the world, 2017

Publications

  1. Kashani AH. Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFm1-9.
  2. Kashani AH, Zhang Y, Capone A, Jr., Drenser KA, Puliafito C, Moshfeghi AA, Williams GA, Trese MT. Impaired Retinal Perfusion Resulting from Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):1-11.
  3. Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani AH. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):362-70.
  4. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral Domain Optical Coherence Tomography Angiography (Sd-Octa). Am J Ophthalmol. 2016 Nov;171:101-12.
  5. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal Implantation of a Monolayer of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: A Feasibility and Safety Study in Yucatan Minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1553-65.
  6. Moysidis SN, Koulisis N, Patel VR, Kashani AH, Rao NA, Humayun MS, Rodger DC. The Second Blind Spot: Small Retinal Vessel Vasculopathy after Vaccination against Neisseria Meningitidis and Yellow Fever. Retin Cases Brief Rep. Epub 2016 Sep 2.
  7. Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016;11(3):e0149961.
  8. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, et al. Stem Cell-Based Therapies for Age-Related Macular Degeneration: The Promises and the Challenges. Progress in Retinal and Eye Research. 2015;48:1-39. Epub 2015/06/27. doi: 10.1016/j.preteyeres.2015.06.004. PubMed PMID: 26113213.
  9. Murali K, Kashani AH, Humayun MS. Whole Vitreous Humor Dissection for Vitreodynamic Analysis. Journal of Visualized Experiments : JoVE. 2015(99):e52759. Epub 2015/06/13. doi: 10.3791/52759. PubMed PMID: 26065393; PubMed Central PMCID: PMCPmc4532330.
  10. Kashani AH, Cheung AY, Robinson J, Williams GA. Longitudinal Optical Density Analysis of Subretinal Fluid after Surgical Repair of Rhegmatogenous Retinal Detachment. Retina (Philadelphia, Pa). 2015;35(1):149-56. Epub 2014/08/01. doi: 10.1097/iae.0000000000000267. PubMed PMID: 25077533.
  11. Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani AH, et al. Profile of Ocriplasmin and its Potential in the Treatment of Vitreomacular Adhesion. Clinical Ophthalmology (Auckland, NZ). 2014;8:847-56. Epub 2014/05/23. doi: 10.2147/opth.s32274. PubMed PMID: 24851038; PubMed Central PMCID: PMCPmc4018320.
  12. Murad-Kejbou S, Kashani AH, Capone A, Jr., Ruby A. Staphylococcus Lugdunensis Endophthalmitis after Intravitreal Injection: A Case Series. Retinal Cases & Brief Reports. 2014;8(1):41-4. Epub 2014/11/06. doi: 10.1097/ICB.0b013e3182a85a4f. PubMed PMID: 25372206.
  13. Matsunaga D, Yi J, Puliafito CA, Kashani AH. OCT Angiography in Healthy Human Subjects. Ophthalmic Surgery, Lasers & Imaging Retina. 2014;45(6):510-5. Epub 2014/11/26. doi: 10.3928/23258160-20141118-04. PubMed PMID: 25423629.
  14. Kashani AH, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. Noninvasive Assessment of Retinal Vascular Oxygen Content Among Normal and Diabetic Human Subjects: A Study using Hyperspectral Computed Tomographic Imaging Spectroscopy. Retina (Philadelphia, Pa). 2014;34(9):1854-60. Epub 2014/04/16. doi: 10.1097/iae.0000000000000146. PubMed PMID: 24732694; PubMed Central PMCID: PMCPmc4145024.
  15. Kashani AH, Learned D, Nudleman E, Drenser KA, Capone A, Trese MT. High Prevalence of Peripheral Retinal Vascular Anomalies in Family Members of Patients with Familial Exudative Vitreoretinopathy. Ophthalmology. 2014;121(1):262-8. Epub 2013/10/03. doi: 10.1016/j.ophtha.2013.08.010. PubMed PMID: 24084499.
  16. Kashani AH, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of Retinal Vascular Anomalies in Patients with Familial Exudative Vitreoretinopathy. Ophthalmology. 2014;121(11):2220-7. Epub 2014/07/10. doi: 10.1016/j.ophtha.2014.05.029. PubMed PMID: 25005911.
  17. Cheung AY, Kashani AH, Drenser KA. Subretinal Peripapillary Neovascularization Associated with Persistent Fetal Vasculature. Retinal Cases & Brief Reports. 2014;8(1):83-6. Epub 2014/11/06. doi: 10.1097/icb.0000000000000010. PubMed PMID: 25372216.
  18. Kashani AH, Eliott D. The Emergence of Klebsiella Pneumoniae Endogenous Endophthalmitis in the USA: Basic and Clinical Advances. Journal of Ophthalmic Inflammation and Infection. 2013;3(1):28. Epub 2013/03/22. doi: 10.1186/1869-5760-3-28. PubMed PMID: 23514342; PubMed Central PMCID: PMCPmc3605079.
  19. Kashani AH, Aaberg TM, Jr., Capone A, Jr. Vitreomacular Traction as a Consequence of Posterior Hyaloidal Contraction after Transpupillary Thermotherapy. American Journal of Ophthalmology. 2013;155(5):937-45. Epub 2013/01/29. doi: 10.1016/j.ajo.2012.11.017. PubMed PMID: 23352339.
  20. Alkin Z, Kashani AH, Lopez-Jaime GR, Ruiz Garcia H, Humayun MS, Sadda SR. Quantitative Analysis of Retinal Structures using Spectral Domain Optical Coherence Tomography in Normal Rabbits. Current Eye Research. 2013;38(2):299-304. Epub 2013/02/05. doi: 10.3109/02713683.2012.757625. PubMed PMID: 23373715.
  21. Trese MT, Kashani AH. Advances in the Diagnosis, Management and Pathophysiology of Capillary Nonperfusion. Expert Review of Ophthalmology. 2012;7(3):281-92. doi: 10.1586/eop.12.26.
  22. Jaime GR, Kashani AH, Saati S, Martin G, Chader G, Humayun MS. Acute Variations in Retinal Vascular Oxygen Content in a Rabbit Model of Retinal Venous Occlusion. PloS One. 2012;7(11):e50179. Epub 2012/11/28. doi: 10.1371/journal.pone.0050179. PubMed PMID: 23185567; PubMed Central PMCID: PMCPmc3502464.
  23. Kashani AH, Kirkman E, Martin G, Humayun MS. Hyperspectral Computed Tomographic Imaging Spectroscopy of Vascular Oxygen Gradients in the Rabbit Retina in vivo. PloS One. 2011;6(9):e24482. Epub 2011/09/21. doi: 10.1371/journal.pone.0024482. PubMed PMID: 21931729; PubMed Central PMCID: PMCPmc3172231.
  24. Kashani AH, Eliott D. Bilateral Klebsiella Pneumoniae (K1 Serotype) Endogenous Endophthalmitis as the Presenting Sign of Disseminated Infection. Ophthalmic Surgery, Lasers & Imaging : The Official Journal of the International Society for Imaging in the Eye. 2011;42 Online:e12-4. Epub 2011/02/18. doi: 10.3928/15428877-20110203-02. PubMed PMID: 21323188.
  25. Kashani AH, Zimmer-Galler IE, Shah SM, Dustin L, Do DV, Eliott D, et al. Retinal Thickness Analysis by Race, Gender, and Age using Stratus OCT. American Journal of Ophthalmology. 2010;149(3):496-502.e1. Epub 2010/01/01. doi: 10.1016/j.ajo.2009.09.025. PubMed PMID: 20042179; PubMed Central PMCID: PMCPmc2826608.
  26. Kashani AH, Keane PA, Dustin L, Walsh AC, Sadda SR. Quantitative Subanalysis of Cystoid Spaces and Outer Nuclear Layer using Optical Coherence Tomography in Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. 2009;50(7):3366-73. Epub 2009/01/27. doi: 10.1167/iovs.08-2691. PubMed PMID: 19168893; PubMed Central PMCID: PMCPmc2908154.
  27. Kashani AH, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, et al. Calcium Activation of the LMO4 Transcription Complex and its role in the Patterning of Thalamocortical Connections. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience. 2006;26(32):8398-408. Epub 2006/08/11. doi: 10.1523/jneurosci.0618-06.2006. PubMed PMID: 16899735.
  28. Kim PM, Aizawa H, Kim PS, Huang AS, Wickramasinghe SR, Kashani AH, et al. Serine Racemase: Activation by Glutamate Neurotransmission via Glutamate Receptor Interacting Protein and Mediation of Neuronal Migration. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(6):2105-10. Epub 2005/02/03. doi: 10.1073/pnas.0409723102. PubMed PMID: 15684087; PubMed Central PMCID: PMCPmc548584.
  29. Grinnell AD, Chen BM, Kashani A, Lin J, Suzuki K, Kidokoro Y. The Role of Integrins in the Modulation of Neurotransmitter Release from Motor Nerve Terminals by Stretch and Hypertonicity. Journal of Neurocytology. 2003;32(5-8):489-503. Epub 2004/03/23. doi: 10.1023/B:NEUR.0000020606.58265.b5. PubMed PMID: 15034249.
  30. Yaghmai R, Kashani AH, Geraghty MT, Okoh J, Pomper M, Tangerman A, et al. Progressive Cerebral Edema Associated with High Methionine Levels and Betaine Therapy in a Patient with Cystathionine Beta-Synthase (CBS) Deficiency. American Journal of Medical Genetics. 2002;108(1):57-63. Epub 2002/02/22. PubMed PMID: 11857551.
  31. Redmond L, Kashani AH, Ghosh A. Calcium Regulation of Dendritic Growth via CaM Kinase IV and CREB-Mediated Transcription. Neuron. 2002;34(6):999-1010. Epub 2002/06/28. PubMed PMID: 12086646.
  32. Kashani AH, Hutchins GM. Meningeal-Cutaneous Relationships in Anencephaly: Evidence for a Primary Mesenchymal Abnormality. Human Pathology. 2001;32(5):553-8. Epub 2001/05/31. doi: 10.1053/hupa.2001.24318. PubMed PMID: 11381375.
  33. Kashani AH, Chen BM, Grinnell AD. Hypertonic Enhancement of Transmitter Release from Frog Motor Nerve Terminals: Ca2+ Independence and Role of Integrins. The Journal of Physiology. 2001;530(Pt 2):243-52. Epub 2001/02/24. PubMed PMID: 11208972; PubMed Central PMCID: PMCPmc2278411.
  34. Yoshizumi MO, Kashani A, Palmer J, Lee G, Mondino B. High Dose Intramuscular Methylprednisolone in Experimental Staphylococcus Aureus Endophthalmitis. Journal of Ocular Pharmacology and Therapeutics : The Official Journal of the Association for Ocular Pharmacology and Therapeutics. 1999;15(1):91-6. Epub 1999/02/27. PubMed PMID: 10048352.
  35. Yoshizumi MO, Bhavsar AR, Dessouki A, Kashani A. Safety of Repeated Intravitreous Injections of Antibiotics and Dexamethasone. Retina (Philadelphia, Pa). 1999;19(5):437-41. Epub 1999/11/05. PubMed PMID: 10546941.