DoctorsXuejuan Jiang, PhD

Xuejuan Jiang, PhD

Xuejuan Jiang, PhD

Title: Assistant Professor of Research Ophthalmology and Preventive Medicine

Department: Ophthalmology

Research Topics:

Optical Coherence Tomography Measurements
Neuro-Degeneration and Aging
Clinical Topics:
Diabetic Retinopathy
Open-Angle Glaucoma
Angle-Closure
Myopia and Pathological Myopia

Biography and Education

Biography:

Xuejuan Jiang received a BS with Honors in Molecular and Cellular Biology from University of Science and Technology of China in 2002. Subsequently, she joined the graduate program in Biomedical and Biological Sciences (PIBBS) at University of Southern California (USC), and received a M.S. in Applied Biostatistics and Epidemiology and a PhD in Epidemiology. At USC, Dr. Jiang investigated how smoking affects bladder cancer risk. Her research provided strong evidence supporting that 1) second-hand smoke can increase bladder cancer risk in female lifelong nonsmokers, 2) genetic variations associated with nicotine dependence and smoking behavior can also affect bladder cancer risk, and 3) use of non-steroidal anti-inflammatory may attenuate the carcinogenic effect of cigarette smoking on the bladder. In addition, she found that factors associated with prolonged exposure to carcinogens in the urine, e.g. infrequent drinking and urination, may increase bladder cancer risk. After earning her doctorate, Dr. Jiang became a postdoctoral research associate at USC, where she focused on using pathway-based systemic approaches to investigate genetic components of adolescent alcohol drinking, bladder cancer, and colorectal cancer, and developing noninvasive biomarkers of oxidative stress. Dr. Jiang joined USC’s Department of Ophthalmology as an Assistant Professor of Research in 2011.

Research Interests:

As an experienced epidemiologist, Xuejuan Jiang, PhD, has expertise in designing, managing and analyzing epidemiological studies to evaluate the impact of different environmental and genetic risk factors, on various cancers, adolescent smoking/drinking behaviors, and ocular disorders. In particular, Dr. Jiang’s research on ocular disease focuses on etiologies of glaucoma, diabetic retinopathy, and refractive errors, especially myopia, identifying early indicators of disease development and progression, and developing possible prevention, intervention and treatments.

Dr. Jiang is currently leading the international effort in consolidating all existing population-based studies of eye diseases among preschool children, to create the largest repository of population-based survey data on vision health among preschool children. Results from this project will improve our understanding of the risk factors for the most common pediatric vision disorders among preschool children, and help inform and develop evidence-based guidelines for population screening and clinical management.

Education:

  • University of Science and Technology of China, Molecular and Cellular Biology, BS, 2002
  • University of Southern California, Applied Biostatistics & Epidemiology, MS, 2004
  • University of Southern California, Epidemiology, PhD, 2007

Other WEB Profiles:

http://profiles.sc-ctsi.org/xuejuan.jiang

Accomplishments

Awards:

  • USTC, Honor Graduate, 2002
  • USC, International Student Academic Achievement Award, 2005

Publications:

  1. Jiang X, Varma R, Torres M, Hsu C, McKean-Cowdin R. Self-Reported Use of Eye Care among Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2017 Apr;176:183-93.
  2. Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rueger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG, Ng MC, Mudgal P, Rivas MA, Vedantam S, Mahajan A, Guo X, Abecasis G, Aben KK, Adair LS, Alam DS, Albrecht E, Allin KH, Allison M, Amouyel P, Appel EV, Arveiler D, Asselbergs FW, Auer PL, Balkau B, Banas B, Bang LE, Benn M, Bergmann S, Bielak LF, Bluher M, Boeing H, Boerwinkle E, Boger CA, Bonnycastle LL, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Burt AA, Butterworth AS, Carey DJ, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Cuellar-Partida G, Danesh J, Davies G, de Bakker PI, de Borst GJ, de Denus S, de Groot MC, de Mutsert R, Deary IJ, Dedoussis G, Demerath EW, den Hollander AI, Dennis JG, Di Angelantonio E, Drenos F, Du M, Dunning AM, Easton DF, Ebeling T, Edwards TL, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Faul JD, Feitosa MF, Feng S, Ferrannini E, Ferrario MM, Ferrieres J, Florez JC, Ford I, Fornage M, Franks PW, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Giedraitis V, Giri A, Girotto G, Gordon SD, Gordon-Larsen P, Gorski M, Grarup N, Grove ML, Gudnason V, Gustafsson S, Hansen T, Harris KM, Harris TB, Hattersley AT, Hayward C, He L, Heid IM, Heikkila K, Helgeland O, Hernesniemi J, Hewitt AW, Hocking LJ, Hollensted M, Holmen OL, Hovingh GK, Howson JM, Hoyng CB, Huang PL, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jhun MA, Jia Y, Jiang X, Johansson S, Jorgensen ME, Jorgensen T, Jousilahti P, Jukema JW, Kahali B, Kahn RS, Kahonen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SL, Karpe F, Kee F, Keeman R, Kiemeney LA, Kitajima H, Kluivers KB, Kocher T, Komulainen P, Kontto J, Kooner JS, Kooperberg C, Kovacs P, Kriebel J, Kuivaniemi H, Kury S, Kuusisto J, La Bianca M, Laakso M, Lakka TA, Lange EM, Lange LA, Langefeld CD, Langenberg C, Larson EB, Lee IT, Lehtimaki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin LA, Lin X, Lind L, Lindstrom J, Linneberg A, Liu Y, Liu Y, Lophatananon A, Luan J, Lubitz SA, Lyytikainen LP, Mackey DA, Madden PA, Manning AK, Mannisto S, Marenne G, Marten J, Martin NG, Mazul AL, Meidtner K, Metspalu A, Mitchell P, Mohlke KL, Mook-Kanamori DO, Morgan A, Morris AD, Morris AP, Muller-Nurasyid M, Munroe PB, Nalls MA, Nauck M, Nelson CP, Neville M, Nielsen SF, Nikus K, Njolstad PR, Nordestgaard BG, Ntalla I, O’Connel JR, Oksa H, Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CN, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JR, Person TN, Pirie A, Polasek O, Posthuma D, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renstrom F, Ridker PM, Rioux JD, Robertson N, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sandow K, Sapkota Y, Sattar N, Schmidt MK, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah S, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith JA, Southam L, Spector TD, Speliotes EK, Starr JM, Steinthorsdottir V, Stringham HM, Stumvoll M, Surendran P, t Hart LM, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorsteinsdottir U, Thuesen BH, Tonjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Ulivi S, van der Laan SW, Van Der Leij AR, van Duijn CM, van Schoor NM, van Setten J, Varbo A, Varga TV, Varma R, Edwards DR, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vozzi D, Walker M, Wang F, Wang CA, Wang S, Wang Y, Wareham NJ, Warren HR, Wessel J, Willems SM, Wilson JG, Witte DR, Woods MO, Wu Y, Yaghootkar H, Yao J, Yao P, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zheng H, Zhou W, Rotter JI, Boehnke M, Kathiresan S, McCarthy MI, Willer CJ, Stefansson K, Borecki IB, Liu DJ, North KE, Heard-Costa NL, Pers TH, Lindgren CM, Oxvig C, Kutalik Z, Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G. Rare and Low-Frequency Coding Variants Alter Human Adult Height. Nature. 2017 Feb;542(7640):186-90.
  3. Richter GM, Wang M, Jiang X, Wu S, Wang D, Torres M, Choudhury F, Varma R. Ocular Determinants of Refractive Error and Its Age- and Sex-Related Variations in the Chinese American Eye Study. JAMA Ophthalmol. 2017 Jul;135(7):724-32.
  4. Varma R, Jiang X. Use of Structural End Points in Glaucoma: Beyond Visual Field Loss. JAMA Ophthalmol. 2017 Jul;135(7):789-90.
  5. Varma R, Tarczy-Hornoch K, Jiang X. Visual Impairment in Preschool Children in the United States: Demographic and Geographic Variations from 2015 to 2060. JAMA Ophthalmol. 2017 Jun;135(6):610-6.
  6. Varma R, Torres M, McKean-Cowdin R, Rong F, Hsu C, Jiang X. Prevalence and Risk Factors for Refractive Error in Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2017 Mar;175:201-12.
  7. Li Y, Ma J, Martin K, Yu M, Ma T, Dayton P, Jiang X, Shung K, Zhou Q. An Integrated System for Super-Harmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Study. IEEE Trans Biomed Eng. Epub 2015 Dec 8.
  8. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral Domain Optical Coherence Tomography Angiography (Sd-Octa). Am J Ophthalmol. 2016 Nov;171:101-12.
  9. Xu BY, Israelsen P, Pan BX, Wang D, Jiang X, Varma R. Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6313-9.
  10. Varma R, Torres M, McKean-Cowdin R, Rong F, Hsu C, Jiang X. Prevalence of Refractive Error in Adult Chinese Americans: The Chinese American Eye Study. Am J Ophthalmol. 2016 Oct 18.
  11. Varma R, Jiang X. The Role of Contextual Factors in Racial/Ethnic Disparities in Eye Care Use. JAMA Ophthalmol. Epub 2016 Aug 25.
  12. Varma R, Wen G, Jiang X, Hsu C, Torres M, Klein R, Azen SP, McKean-Cowdin R. Prevalence of Diabetic Retinopathy in Adult Chinese American Individuals: The Chinese American Eye Study. JAMA Ophthalmol. Epub 2016 Apr 7.
  13. Goossens ME, Isa F, Brinkman M, Mak D, Reulen R, Wesselius A, Benhamou S, Bosetti C, Bueno-de-Mesquita B, Carta A, Allam MF, Golka K, Grant EJ, Jiang X, Johnson KC, Karagas MR, Kellen E, La Vecchia C, Lu CM, Marshall J, Moysich K, Pohlabeln H, Porru S, Steineck G, Stern MC, Tang L, Taylor JA, van den Brandt P, Villeneuve PJ, Wakai K, Weiderpass E, White E, Wolk A, Zhang ZF, Buntinx F, Zeegers MP. International Pooled Study on Diet and Bladder Cancer: The Bladder Cancer, Epidemiology and Nutritional Determinants (Blend) Study: Design and Baseline Characteristics. Arch Public Health. 2016;74:30.
  14. Jiang X, Tseng CC, Bernstein L, Wu AH. Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study. BMC cancer. 2014;14:60. Epub 2014/02/06. doi: 10.1186/1471-2407-14-60. PubMed PMID: 24495377; PubMed Central PMCID: PMCPmc3915076.
  15. Mitra AP, Castelao JE, Hawes D, Tsao-Wei DD, Jiang X, Shi SR, et al. Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program. Cancer. 2013;119(4):756-65. Epub 2013/01/16. doi: 10.1002/cncr.27763. PubMed PMID: 23319010; PubMed Central PMCID: PMCPmc3565093.
  16. Jiang X, Castelao JE, Vandenberg D, Carracedo A, Redondo CM, Conti DV, et al. Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PloS one. 2013;8(4):e60464. Epub 2013/04/06. doi: 10.1371/journal.pone.0060464. PubMed PMID: 23560096; PubMed Central PMCID: PMCPmc3616155.
  17. Redondo CM, Gago-Dominguez M, Ponte SM, Castelo ME, Jiang X, Garcia AA, et al. Breast feeding, parity and breast cancer subtypes in a Spanish cohort. PloS one. 2012;7(7):e40543. Epub 2012/07/14. doi: 10.1371/journal.pone.0040543. PubMed PMID: 22792365; PubMed Central PMCID: PMCPmc3394701.
  18. Jiang X, Varma R, Wu S, Torres M, Azen SP, Francis BA, et al. Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study. Ophthalmology. 2012;119(11):2245-53. Epub 2012/07/17. doi: 10.1016/j.ophtha.2012.05.030. PubMed PMID: 22796305; PubMed Central PMCID: PMCPmc3474872.
  19. Jiang X, Castelao JE, Yuan JM, Stern MC, Conti DV, Cortessis VK, et al. Cigarette smoking and subtypes of bladder cancer. International journal of cancer Journal international du cancer. 2012;130(4):896-901. Epub 2011/03/18. doi: 10.1002/ijc.26068. PubMed PMID: 21412765; PubMed Central PMCID: PMCPmc3210924.
  20. Jiang X, Castelao JE, Chavez-Uribe E, Fernandez Rodriguez B, Celeiro Munoz C, Redondo CM, et al. Family history and breast cancer hormone receptor status in a Spanish cohort. PloS one. 2012;7(1):e29459. Epub 2012/01/13. doi: 10.1371/journal.pone.0029459. PubMed PMID: 22238615; PubMed Central PMCID: PMCPmc3253097.
  21. Jiang X, Bernstein L, Tseng CC, Wu AH. Diabetes and risk of esophageal and gastric adenocarcinomas. International journal of cancer Journal international du cancer. 2012;131(6):1417-22. Epub 2011/12/14. doi: 10.1002/ijc.27390. PubMed PMID: 22161620; PubMed Central PMCID: PMCPmc3340473.
  22. Li D, London SJ, Liu J, Lee W, Jiang X, Van Den Berg D, et al. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. American journal of epidemiology. 2011;173(9):1039-48. Epub 2011/03/19. doi: 10.1093/aje/kwq471. PubMed PMID: 21415033; PubMed Central PMCID: PMCPmc3121219.
  23. Gago-Dominguez M, Jiang X, Conti DV, Castelao JE, Stern MC, Cortessis VK, et al. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011;32(2):197-202. Epub 2010/11/18. doi: 10.1093/carcin/bgq233. PubMed PMID: 21081471; PubMed Central PMCID: PMCPmc3026841.
  24. Jiang X, Castelao JE, Yuan JM, Groshen S, Stern MC, Conti DV, et al. Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010;31(11):1964-71. Epub 2010/08/25. doi: 10.1093/carcin/bgq173. PubMed PMID: 20732908; PubMed Central PMCID: PMCPmc2966553.
  25. Cortessis VK, Yuan JM, Van Den Berg D, Jiang X, Gago-Dominguez M, Stern MC, et al. Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(12):3150-6. Epub 2010/11/06. doi: 10.1158/1055-9965.epi-10-0763. PubMed PMID: 21051319; PubMed Central PMCID: PMCPmc3417222.
  26. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata D, Conti DV, et al. Urinary tract infections and reduced risk of bladder cancer in Los Angeles. British journal of cancer. 2009;100(5):834-9. Epub 2009/01/29. doi: 10.1038/sj.bjc.6604889. PubMed PMID: 19174821; PubMed Central PMCID: PMCPmc2653778.
  27. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata DK, Conti DV, et al. Water intake and bladder cancer risk in Los Angeles County. International journal of cancer Journal international du cancer. 2008;123(7):1649-56. Epub 2008/07/16. doi: 10.1002/ijc.23711. PubMed PMID: 18623082.
  28. Jiang X, Yuan JM, Skipper PL, Tannenbaum SR, Yu MC. Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County. Cancer research. 2007;67(15):7540-5. Epub 2007/08/03. doi: 10.1158/0008-5472.can-07-0048. PubMed PMID: 17671226.
  29. Jiang X, Castelao JE, Groshen S, Cortessis VK, Ross RK, Conti DV, et al. Alcohol consumption and risk of bladder cancer in Los Angeles County. International journal of cancer Journal international du cancer. 2007;121(4):839-45. Epub 2007/04/19. doi: 10.1002/ijc.22743. PubMed PMID: 17440923.
  30. Gago-Dominguez M, Jiang X, Esteban Castelao J. Lipid peroxidation and the protective effect of physical exercise on breast cancer. Medical hypotheses. 2007;68(5):1138-43. Epub 2006/11/23. doi: 10.1016/j.mehy.2006.09.026. PubMed PMID: 17113718.
  31. Gago-Dominguez M, Jiang X, Castelao JE. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. Breast cancer research : BCR. 2007;9(1):201. Epub 2007/01/17. doi: 10.1186/bcr1628. PubMed PMID: 17224037; PubMed Central PMCID: PMCPmc1851400.