DoctorsMahnaz Shahidi, PhD

Mahnaz Shahidi, PhD

Mahnaz Shahidi, PhD

Title: Professor of Ophthalmology and Biomedical Engineering, Riffenburgh Professor in Glaucoma, Vice Chair for Translational Research, Department of Ophthalmology

Department: Ophthalmology

Clinical Specialty: Diabetic Retinopathy, Sickle Cell Retinopathy, Age-related Macular Degeneration, Glaucoma

Research Topics:

Ocular Imaging Technology
Ocular Hemodynamics
Neurovascular Coupling
Retinal Oxygen Metabolism
Image-based Biomarkers of Disease

Biography and Education

Research Interests:

The research of Mahnaz Shahidi, PhD, is focused on development and application of prototype optical imaging technologies to study pathophysiology and improve diagnostic evaluation of ocular and systemic diseases. Ongoing research projects include: imaging of retinal oxygen delivery and metabolism in experimental models of retinal diseases, characterization of microvascular hemodynamics in ocular and systemic diseases, identification of image-based biomarkers of diabetic retinopathy, and assessment of retinal neurovascular coupling and oxygen metabolism in diabetic retinopathy, sickle cell retinopathy and glaucoma.


  • PhD, Physics, University of Illinois, 1988



  • Juvenile Diabetes Foundation Fellowship Award, 1992
  • The Whitaker Foundation Award, 1995
  • Senior Scientific Investigator Award, Research to Prevent Blindness, 2009
  • Morton F. Goldberg, MD, FACS Professorship, 2010
  • UIC Inventor of the Year Award, 2012
  • UIC Faculty of the Year Award, 2014


  1. Blair NP, Wanek J, Felder AE, Joslin CE, Kresovich JK, Lim JI, Chau FY, Leiderman Y, Shahidi M. Retinal Oximetry and Vessel Diameter Measurements with a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 Oct;58(12):5556-63.
  2. Felder AE, Wanek J, Blair NP, Shahidi M. Retinal Vascular and Oxygen Temporal Dynamic Responses to Light Flicker in Humans. Invest Ophthalmol Vis Sci. 2017 Nov;58(13):5666-72.
  3. Felder AE, Wanek J, Tan MR, Blair NP, Shahidi M. A Method for Combined Retinal Vascular and Tissue Oxygen Tension Imaging. Sci Rep. 2017 Sep;7(1):10622.
  4. Felder AE, Wanek J, Teng PY, Blair NP, Shahidi M. A Method for Volumetric Retinal Tissue Oxygen Tension Imaging. Curr Eye Res. 2017 Sep:1-6
  5. Khansari MM, O’Neill W, Lim J, Shahidi M. Method for Quantitative Assessment of Retinal Vessel Tortuosity in Optical Coherence Tomography Angiography Applied to Sickle Cell Retinopathy. Biomed Opt Express. 2017 Aug;8(8):3796-806.
  6. Khansari MM, Wanek J, Tan M, Joslin CE, Kresovich JK, Camardo N, Blair NP, Shahidi M. Assessment of Conjunctival Microvascular Hemodynamics in Stages of Diabetic Microvasculopathy. Sci Rep. 2017 Apr;7:45916.
  7. Park JC, Chen YF, Blair NP, Chau FY, Lim JI, Leiderman YI, Shahidi M, McAnany JJ. Pupillary Responses in Non-Proliferative Diabetic Retinopathy. Sci Rep. 2017 Mar;7:44987.
  8. Kord Valeshabad A, Wanek J, Zelkha R, Lim JI, Camardo N, Gaynes B, Shahidi M. Conjunctival Microvascular Hemodynamics in Sickle Cell Retinopathy Subjects with Focal Macular Thinning. Acta Ophthalmol. 2015. 93(4):e275-80. PMID: 25429907
  9. Abbasian J, Blair NP, Shahidi M, Ying G, Huang J, Kaufman L, Blair M. Macular coherence tomography in patients with unilateral optic nerve hypoplasia, J AAPOS. 2015 Feb; 19(1):57-61. PMID: 25727589
  10. Kord Valeshabad A, Wanek J, McAnany J, Shahidi M. Effects of Optical Blur Reduction on Equivalent Intrinsic Blur. Optom Vis Sci. 2015 Apr; 92(4):494-9. PMID: 25785538
  11. Kord Valeshabad A, Mieler WF, Setlur V, Thomas M, Shahidi M. Posterior Segment Toxicity after Gemcitabine and Docetaxel Chemotherapy. Optom Vis Sci. 2015. 92(5): e110-3. PMID: 25822016
  12. Lim JI, Zelkha R, Niec M, Setlur V, Shahidi M. Inner and Outer Retinal Thickness Mapping of Non-proliferative Diabetic Retinopathy by Spectral Domain Optical Coherence Tomography. Ophthalmic Surg Lasers Imaging Retina. 2015. 46(3):316-20. PMID: 25856816
  13. Kord Valeshabad A, Francis AW, Setlur V, Chang P, Mieler WF, Shahidi M. Hemorrhagic Retinopathy Following Spondylosis Surgery and Seizure. Optom Vis Sci. 2015. 92(8):e190-3. PMID: 26099062
  14. Mohammad F, Ansari R, Wanek J, Shahidi M. Feasibility of level-set analysis of Enface OCT retinal images in diabetic retinopathy. Biomed Optics Exp. 2015. 6(5): 1904-18. PMID: 26137390
  15. Kord Valeshabad A, Wanek J, Mukarram F, Zelkha R, Testai F, Shahidi M. Feasibility of Assessment of Conjunctival Microvascular Hemodynamics in Unilateral Ischemic Stroke. Microvascular Research. 2015. 100: 4-8. PMID: 25917010
  16. Kord Valeshabad A, Wanek J, Saraf SL, Gaynes B, Gordeuk V, Molokie R, Shahidi M. Changes in Conjunctival Hemodynamics Predict Albuminuria in Early Stages of Sickle Cell Nephropathy. Am J Nephrol. 2015. 41(6):487-93. PMID: 26278102
  17. Kord Valeshabad A, Wanek J, Gaynes B, Saraf SL, Molokie R, Shahidi M. Conjunctival microvascular hemodynamics following vaso-occlusive crisis in sickle cell disease. Clin Hemorheol Microcirc. 2015 Sep 25;62(4):359-67. PMID: 26444608
  18. Felder A, Wanek J, Blair NP, Shahidi M. Inner Retinal Oxygen Extraction Fraction in Response to Light Flicker Stimulation in Humans. Invest Ophthalmol Vis Sci. 2015. 56(11):6633-7. PMID: 26469748
  19. Khansari M, Wanek J, Camardo N, Shahidi M. Automated Assessment of Hemodynamics in the Conjunctival Microvasculature Network. IEEE Transactions on Medical Imaging. 2015. 35(2):605-11. PMID: 26452274
  20. Kord Valeshabad A, Wanek J, Molokie R, Machado R, Gordeuk V, Shahidi M. Conjunctival and Pulmonary Hemodynamics Properties in Sickle Cell Disease Subjects with and without Pulmonary Hypertension. Clinical Cases Reports. 2015. 3(12):1038-41. PMID: 26734142
  21. Francis AW, Wanek J, Lim JI, Shahidi M. Enface Thickness Mapping and Reflectance Imaging of Retinal Layers in Diabetic Retinopathy. PLoS One. 2015. 10(12):e0145628. PMID: 26699878
  22. Blair NP, Wanek J, Teng P, Shahidi M. The Effect of Intravitreal Vascular Endothelial Growth Factor on Inner Retinal Oxygen Delivery and Metabolism in Rats. Experimental Eye Research. 2016. 143:141-7. PMID: 26518179
  23. Felder A, Mercurio C, Wanek J, Ansari R, Shahidi M. Automated Real-time Conjunctival Microvasculature Image Stabilization. IEEE Transactions on Medical Imaging. 2016. 35(7):1670-5. PMID: 26863649
  24. Wanek J, Blair NP, Chau FY, Lim JI, Leiderman YI, Shahidi M. Alterations in Retinal Layer Thickness and Reflectance at Different Stages of Diabetic Retinopathy by Enface Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2016. 57(9):OCT341-7. PMID: 27409491
  25. Khansari MM, O’Neill W, Penn R, Blair NP, Chau F., Shahidi M. An Automated Fine Structure Image Analysis Method for Discrimination of Diabetic Retinopathy Using Conjunctival Microvasculature Images. BioMed Optics Express. 2016. 7(7):2597-606. PMID: 27446692
  26. Felder A, Wanek J, Blair NP, Joslin C, Brewer K, Chau F, Lim JI, Leiderman Y, Shahidi M. Effects of Diabetic Retinopathy Stage and Light Flicker on Retinal Oxygen Extraction Fraction. Invest Ophthalmol Vis Sci. 2016. 57(13):5586-5592. PMID: 27768785
  27. Blair NP, Wanek J, Felder AE, Shahidi M. Inner Retinal Oxygen Delivery and Metabolism in Ins2 (Akita) Diabetic Mice. Invest Ophthalmol Vis Sci. 2016. 57(14):5903-5909. PMID: 27802520