< BackResearch FacultyXuejuan Jiang, PhD

Xuejuan Jiang, PhD

Xuejuan-Jiang-2323-200x300

Assistant Professor of Research Ophthalmology and Preventive Medicine

Research Topics:

Optical Coherence Tomography Measurements
Neuro-Degeneration and Aging
Clinical Topics:
Diabetic Retinopathy
Open-Angle Glaucoma
Angle-Closure
Myopia and Pathological Myopia

Research Interests:

As an experienced epidemiologist, Xuejuan Jiang, PhD, has expertise in designing, managing and analyzing epidemiological studies to evaluate the impact of different environmental and genetic risk factors, on various cancers, adolescent smoking/drinking behaviors, and ocular disorders. In particular, Dr. Jiang’s research on ocular disease focuses on etiologies of glaucoma, diabetic retinopathy, and refractive errors, especially myopia, identifying early indicators of disease development and progression, and developing possible prevention, intervention and treatments.

Dr. Jiang is currently leading the international effort in consolidating all existing population-based studies of eye diseases among preschool children, to create the largest repository of population-based survey data on vision health among preschool children. Results from this project will improve our understanding of the risk factors for the most common pediatric vision disorders among preschool children, and help inform and develop evidence-based guidelines for population screening and clinical management.

Biography:

Xuejuan Jiang received a BS with Honors in Molecular and Cellular Biology from University of Science and Technology of China in 2002. Subsequently, she joined the graduate program in Biomedical and Biological Sciences (PIBBS) at University of Southern California (USC), and received a M.S. in Applied Biostatistics and Epidemiology and a PhD in Epidemiology. At USC, Dr. Jiang investigated how smoking affects bladder cancer risk. Her research provided strong evidence supporting that 1) second-hand smoke can increase bladder cancer risk in female lifelong nonsmokers, 2) genetic variations associated with nicotine dependence and smoking behavior can also affect bladder cancer risk, and 3) use of non-steroidal anti-inflammatory may attenuate the carcinogenic effect of cigarette smoking on the bladder. In addition, she found that factors associated with prolonged exposure to carcinogens in the urine, e.g. infrequent drinking and urination, may increase bladder cancer risk. After earning her doctorate, Dr. Jiang became a postdoctoral research associate at USC, where she focused on using pathway-based systemic approaches to investigate genetic components of adolescent alcohol drinking, bladder cancer, and colorectal cancer, and developing noninvasive biomarkers of oxidative stress. Dr. Jiang joined USC’s Department of Ophthalmology as an Assistant Professor of Research in 2011.

Education:

  • University of Science and Technology of China, Molecular and Cellular Biology, BS, 2002
  • University of Southern California, Applied Biostatistics & Epidemiology, MS, 2004
  • University of Southern California, Epidemiology, PhD, 2007

Awards:

  • USTC, Honor Graduate, 2002
  • USC, International Student Academic Achievement Award, 2005

Other web profiles:

http://profiles.sc-ctsi.org/xuejuan.jiang

Publications:

  1. Jiang X, Tseng CC, Bernstein L, Wu AH. Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study. BMC cancer. 2014;14:60. Epub 2014/02/06. doi: 10.1186/1471-2407-14-60. PubMed PMID: 24495377; PubMed Central PMCID: PMCPmc3915076.
  2. Mitra AP, Castelao JE, Hawes D, Tsao-Wei DD, Jiang X, Shi SR, et al. Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program. Cancer. 2013;119(4):756-65. Epub 2013/01/16. doi: 10.1002/cncr.27763. PubMed PMID: 23319010; PubMed Central PMCID: PMCPmc3565093.
  3. Jiang X, Castelao JE, Vandenberg D, Carracedo A, Redondo CM, Conti DV, et al. Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PloS one. 2013;8(4):e60464. Epub 2013/04/06. doi: 10.1371/journal.pone.0060464. PubMed PMID: 23560096; PubMed Central PMCID: PMCPmc3616155.
  4. Redondo CM, Gago-Dominguez M, Ponte SM, Castelo ME, Jiang X, Garcia AA, et al. Breast feeding, parity and breast cancer subtypes in a Spanish cohort. PloS one. 2012;7(7):e40543. Epub 2012/07/14. doi: 10.1371/journal.pone.0040543. PubMed PMID: 22792365; PubMed Central PMCID: PMCPmc3394701.
  5. Jiang X, Varma R, Wu S, Torres M, Azen SP, Francis BA, et al. Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study. Ophthalmology. 2012;119(11):2245-53. Epub 2012/07/17. doi: 10.1016/j.ophtha.2012.05.030. PubMed PMID: 22796305; PubMed Central PMCID: PMCPmc3474872.
  6. Jiang X, Castelao JE, Yuan JM, Stern MC, Conti DV, Cortessis VK, et al. Cigarette smoking and subtypes of bladder cancer. International journal of cancer Journal international du cancer. 2012;130(4):896-901. Epub 2011/03/18. doi: 10.1002/ijc.26068. PubMed PMID: 21412765; PubMed Central PMCID: PMCPmc3210924.
  7. Jiang X, Castelao JE, Chavez-Uribe E, Fernandez Rodriguez B, Celeiro Munoz C, Redondo CM, et al. Family history and breast cancer hormone receptor status in a Spanish cohort. PloS one. 2012;7(1):e29459. Epub 2012/01/13. doi: 10.1371/journal.pone.0029459. PubMed PMID: 22238615; PubMed Central PMCID: PMCPmc3253097.
  8. Jiang X, Bernstein L, Tseng CC, Wu AH. Diabetes and risk of esophageal and gastric adenocarcinomas. International journal of cancer Journal international du cancer. 2012;131(6):1417-22. Epub 2011/12/14. doi: 10.1002/ijc.27390. PubMed PMID: 22161620; PubMed Central PMCID: PMCPmc3340473.
  9. Li D, London SJ, Liu J, Lee W, Jiang X, Van Den Berg D, et al. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. American journal of epidemiology. 2011;173(9):1039-48. Epub 2011/03/19. doi: 10.1093/aje/kwq471. PubMed PMID: 21415033; PubMed Central PMCID: PMCPmc3121219.
  10. Gago-Dominguez M, Jiang X, Conti DV, Castelao JE, Stern MC, Cortessis VK, et al. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011;32(2):197-202. Epub 2010/11/18. doi: 10.1093/carcin/bgq233. PubMed PMID: 21081471; PubMed Central PMCID: PMCPmc3026841.
  11. Jiang X, Castelao JE, Yuan JM, Groshen S, Stern MC, Conti DV, et al. Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010;31(11):1964-71. Epub 2010/08/25. doi: 10.1093/carcin/bgq173. PubMed PMID: 20732908; PubMed Central PMCID: PMCPmc2966553.
  12. Cortessis VK, Yuan JM, Van Den Berg D, Jiang X, Gago-Dominguez M, Stern MC, et al. Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(12):3150-6. Epub 2010/11/06. doi: 10.1158/1055-9965.epi-10-0763. PubMed PMID: 21051319; PubMed Central PMCID: PMCPmc3417222.
  13. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata D, Conti DV, et al. Urinary tract infections and reduced risk of bladder cancer in Los Angeles. British journal of cancer. 2009;100(5):834-9. Epub 2009/01/29. doi: 10.1038/sj.bjc.6604889. PubMed PMID: 19174821; PubMed Central PMCID: PMCPmc2653778.
  14. Jiang X, Castelao JE, Groshen S, Cortessis VK, Shibata DK, Conti DV, et al. Water intake and bladder cancer risk in Los Angeles County. International journal of cancer Journal international du cancer. 2008;123(7):1649-56. Epub 2008/07/16. doi: 10.1002/ijc.23711. PubMed PMID: 18623082.
  15. Jiang X, Yuan JM, Skipper PL, Tannenbaum SR, Yu MC. Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County. Cancer research. 2007;67(15):7540-5. Epub 2007/08/03. doi: 10.1158/0008-5472.can-07-0048. PubMed PMID: 17671226.
  16. Jiang X, Castelao JE, Groshen S, Cortessis VK, Ross RK, Conti DV, et al. Alcohol consumption and risk of bladder cancer in Los Angeles County. International journal of cancer Journal international du cancer. 2007;121(4):839-45. Epub 2007/04/19. doi: 10.1002/ijc.22743. PubMed PMID: 17440923.
  17. Gago-Dominguez M, Jiang X, Esteban Castelao J. Lipid peroxidation and the protective effect of physical exercise on breast cancer. Medical hypotheses. 2007;68(5):1138-43. Epub 2006/11/23. doi: 10.1016/j.mehy.2006.09.026. PubMed PMID: 17113718.
  18. Gago-Dominguez M, Jiang X, Castelao JE. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. Breast cancer research : BCR. 2007;9(1):201. Epub 2007/01/17. doi: 10.1186/bcr1628. PubMed PMID: 17224037; PubMed Central PMCID: PMCPmc1851400.