Research Program

In our mission to preserve, protect and restore sight, the vision researchers at the USC Roski Eye Institute play a critical role in driving fundamental and translational research to advance patient care. Ultimately, the USC Roski Eye Institute seeks to improve lives through scientific discovery and technical innovation that results in new treatments that overcome visual impairment and blindness.

Epidemiology-To preserve and protect our vision, researchers in the field of epidemiology have conducted population-based studies to understand the burden of eye disease both nationally and globally, prevent vision impairment and impact eye health care policy.

Imaging-Groundbreaking work in the field of imaging has allowed researchers to gain in-depth understanding of the anatomy and physiology of the eye for advancing diagnostic techniques to prevent vision loss through early diagnosis and discovery of therapeutic technology. Through an interdisciplinary collaboration with the USC Mark and Mary Stevens Center for Neuroimaging, clinician-scientists utilize informatics and Big Data analytical techniques for neuroimaging, known as the Human Connectome Project (HCP), to study relationships between the eye and the brain to help advance knowledge and diagnostic evaluation of neurodegenerative disorders.

Bioengineering and Nanotechnology-Roski researchers are also converging bioengineering and medicine to develop novel implantable and wearable devices for sight restoration therapies to treat those who suffer from vision loss from conditions such as retinal degenerative diseases. In addition, using the principles of nanotechnology researchers are developing unique drug delivery methods for diseases like dry and wet age-related macular degeneration (AMD), uveitis and glaucoma.

Inflammation and Regeneration-Breakthroughs in the fields of inflammation and regeneration have brought researchers closer to developing new therapies for autoimmune diseases that evoke inflammatory responses like Sjogren’s disease which causes severe dry eye or stem cell research to develop regenerative vision restoration treatments for diseases such as dry age-related macular degeneration for which there is no known cure.

Neuroregeneration-Through fundamental investigations into the basic mechanism of retinal degenerative diseases, scientists also seek to better understand neurodegeneration in diseases such as AMD and retinitis pigmentosa in hopes of one day finding a cure.

Ultimately, the USC Roski Eye Institute mission is to improve lives through scientific discovery and technical innovation that results in new treatments that overcome visual impairment and