USC Retinal Degeneration Center

A part of the USC Roski Eye Institute, the USC Retinal Degeneration Center was established to provide comprehensive ophthalmic care to patients with inherited retinal degenerative diseases and to investigate and develop novel treatments for these conditions. Under the directorship of Hossein Ameri, MD, PhD, the multidisciplinary center provides innovative and cutting-edge diagnostic and therapeutic services through collaboration with other Keck Medicine institutes to ensure that patients are being provided with the most comprehensive and personalized care possible.

We offer a complete spectrum of diagnostic and therapeutic services for the following degenerative retinal diseases:

  • Retinitis pigmentosa
  • Cone dystrophy
  • Usher syndrome
  • Stargardt’s disease
  • Best disease
  • Choroideremia
  • Achromatopsia

Inherited retinal degenerative diseases are rare and patients with these conditions require special care. Through partnership of the USC faculty at the USC Roski Eye Institute and the Children Hospital Los Angeles, the center provides care for both children and adults. We update our patients on the status of available treatments and current clinical trials. We provide Argus II retinal prosthesis implantation for those who suffer from advanced form of retinitis pigmentosa.

Free Genetic Testing

The USC Roski Eye Institute is one of the centers providing free genetic testing through Spark Therapeutics to patients with certain forms of inherited retinal disease (IRD), including leber congenital amaurosis (LCA), retinitis pigmentosa, Usher syndrome and choroideremia (CHM). This test that screens a limited number of genes, may uncover the cause of vision impairment and identify the specific genetic mutation in patients with IRD.

To make an appointment please call (323)442-6335.

In the News

FDA approved the first gene therapy for inherited retinal degeneration on Dec 19, 2017. This is a historical moment and could signal the start of an era that gene therapy could treat many previously untreatable conditions. Soon, eligible Leber’s congenital amaurosis or retinitis pigmentosa patients who have RPE65 gene defect could receive gene therapy through an eye injection.

Diagnostic Services at the Electrophysiology Laboratory

The electrophysiology lab is equipped with state of the art equipment for performing diagnostic tests. We accept external referrals for electrophysiology testing.

  • Electroretingram (ERG)
  • Multifocal ERG
  • Electrooculogram (EOG)
  • Visual Evoked Potential (VEP)
  • Goldmann Visual Field


The research activities at the USC Retinal Degeneration Center include both clinical and basic science research. Our mission is to make scientific discoveries that will benefit patients who suffer from genetic degenerative retinal diseases. Our current research focus is on gene therapy, stem cell based therapies and retinal prosthesis.

Please visit our doctors page for summaries of the basic/translational and clinical research being conducted by our clinicians.

Next, read about our Ophthalmology Treatments.

Our Physicians


Call 323-442-6335 or fill-out our online form to get in touch with a Retina specialist.