Retina, Vitreous and Macular Diseases & Surgery Service

Microglial cell (green) fasciculating closely with radial Müller cell processes (red) in an endotoxin model of retinal inflammation. Reference:

The USC Roski Eye Institute’s Retina service offers state-of-the-art care in the treatment and management of patients who suffer from diseases affecting the retina and vitreous. The Retina service is a highly dedicated team of retina specialists and researchers that have access to the most advanced medical technology in the treatment of retinal diseases, such as diabetic retinopathy, age-related macular degeneration (AMD), and retinitis pigmentosa (RP).

Other common retinal issues that are treated within this service include retinal detachments, macular pucker and macular hole.

The ophthalmologists at the USC Roski Eye Institute have been providing cutting edge eye care for 40 years and provide effective treatments for countless retinal conditions. If you are interested in a consultation with a member of the retinal service, call 323-442-6335 or fill out the online contact form to find out more and receive the eye care you need.

Conditions We Treat


  • Adults with History of Pediatric Retinal Problems
  • Adults with History of Retinopathy of Prematurity (ROP)
  • Angioid Streaks
  • Branch Retinal Vein/Artery Occlusions (Stroke of the Eye)
  • Central Serous Chorioretinopathy
  • Choroidal Hemangioma
  • Choroidal Hemorrhage
  • Choroidal Neovascularization
  • Choroidal Nevi
  • Choroidal Melanoma
  • Coats Disease
  • Diabetic Retinopathy
  • Dry Age Related Macular Degeneration (Dry AMD)
  • Drug-Related Effects on the Retina
  • HIV Retinopathy
  • Hypertensive Retinopathy
  • Infectious Diseases Involving the Retina
  • Inherited Retinal Disease and Degenerations
  • Intraocular Foreign Body
  • Intraocular Lymphoma
  • Macular Degeneration
  • Macular Edema
  • Macular Hole
  • Macular Pucker (Epiretinal Membrane or Cellophane Retinopathy)
  • Macular Telangiectasia
  • Melanoma
  • Myopic Degeneration
  • Pars Planitis
  • Plaquenil Toxicity
  • Posterior Lens Dislocation
  • Posterior Vitreous Detachment (Flashes and Floaters)
  • Proliferative Vitreoretinopathy
  • Radiation Retinopathy
  • Recurrent or Complicated Retinal Detachment
  • Retinal Arterial Macroaneurysm
  • Retinal Complications of Systemic Problems
  • Retinal Degenerations or Dystrophies
  • Retinal Detachment
  • Retinal Holes
  • Retinal Tears
  • Retinitis Pigmentosa
  • Retinoblastoma
  • Retinoschisis
  • Sickle Cell Retinopathy
  • Toxoplasmosis
  • Uveitis (Inflammation of the Eye)
  • Viral or Infectious Retinitis
  • Vitreous Hemorrhage
  • Vogt-Koyanagi-Harada Syndrome (VKH)
  • Wet (Neovascular) Age Related Macular Degeneration (Wet AMD)

Diagnostic Services

Microglia (green) migrating into the developing retina at postnatal day 7 via the developing retinal vasculature and hyaloid vessels (red). Reference:
Microglia (green) migrating into the developing retina at postnatal day 7 via the developing retinal vasculature and hyaloid vessels (red). Reference:

The wide spectrum of retinal diseases can range from minor tears to the retina to more complex diseases like age-related macular degeneration, which can lead to complete vision loss. Retinal diseases can be genetic, occur through injury to the eye, natural aging process or even by other conditions. There are several symptoms associated with retinal diseases such as loss of vision, distorted or blurred vision, loss of peripheral vision or the appearance of floaters. A complete dilated eye exam is required for accurate diagnosis of the disease. The vitreoretinal surgery and retinal diseases service offers the most advanced diagnostic technology:

  • Electroretinogram (ERG)
  • Fundus Photography
  • Fluorescein Angiography
  • Genetic Testing
  • Indocyanine Green Angiography
  • Ocular Ultrasound
  • Optical Coherence Tomography (OCT)
  • Visual Field Testing
  • Widefield Imaging of the Retina

Contact the USC Retina Service


USC retinal surgeons are fellowship-trained experts in complex retinal surgery. Among the common retina surgeries performed, the USC Roski Eye Institute also offers complex retinal procedures such as the Argus II retinal implant surgery offered by only a few eye centers across the United States. Argus II, the first FDA approved artificial retinal prosthesis, was developed at the USC Roski Eye Institute to treat patients suffering from an inherited form of retinitis pigmentosa. The USC retinal surgeons also offer a highly sophisticated camera guided procedure, the endoscopic vitreoretinal surgery, which allows for a clear visual of the retina while operating. Treatments include:

  • Laser Therapy of the Retina
  • Intravitreal Injections (Treatment of Macular Degeneration and Diabetic Retinopathy and Retinal Vein Occlusion)
  • Argus Retinal Prosthesis
  • Pars Plana Vitrectomy (Conventional and Endoscopic)
  • Pneumatic Retinopexy
  • Repair of Macular Holes and Macular Pucker
  • Repair of Retinal Detachments
  • Retina Surgery and Procedures
  • Scleral Buckle
  • Cryotherapy

USC Retinal Degeneration Center

A part of the USC Roski Eye Institute, the USC Retinal Degeneration Center was established to provide comprehensive ophthalmic care to patients with inherited retinal degenerative diseases and to investigate and develop novel treatments for these conditions.

Advances in Retinal Research

  • Microglia cells (green) in an en-face view of the inner plexiform layer in close proximity to retinal capillaries (red). Reference:
    Microglia cells (green) in an en-face view of the inner plexiform layer in close proximity to retinal capillaries (red). Reference:

    Home of Argus II – Co-invented by Drs. Mark Humayun and James Weiland, Argus II, a retinal chip, is the world’s first approved device that gives an unprecedented degree of vision to those suffering from retinitis pigmentosa, a genetic condition that leads to retinal blindness.

  • Stem Cell Treatment for AMD – Dr. Humayun and Dr. David Hinton recently received nearly $19 Million through California Institute for Regenerative Medicine’s (CIRM) Disease Team awards. Drs. Hinton and Humayun’s team have developed a unique procedure by which stem-cell derived cells may be surgically implanted into the back of the eye, replacing diseased retinal cells. The future Phase I human clinical trials are to be conducted at the USC Roski Eye Institute.
  • Sutureless Surgery – a retinal surgery technique now used worldwide, the small guauge sutureless vitrectomy surgery.
  • Invention of optical coherence tomography (OCT) – and imaging technique which revolutionized the diagnosis of retinal diseases.
  • Identifies origin of Retinoblastomas – the most common malignant tumor of the eye in children. Dr. David Cobrinik’s publication in the prestigious journal Nature in 2014, “Rb suppresses human cone-precursor-derived retinoblastoma tumours”, contributes greatly to vision research and the understanding of retinal development and tumorigenesis. This investigation has led to the identification of the cell of origin for retinoblastoma. Moreover, these findings provide a compelling molecular rationale for a cone precursor origin of retinoblastoma. Generally, this demonstrates that cell-type-specific circuitry can collaborate with an initiating oncogenic mutation to enable tumorigenesis.

Our highly skilled retina specialists at the USC Roski Eye Institute provide effective treatment that is tailored to the unique needs of your condition. Contact our ophthalmology team today by filling out the online contact form or dialing 323-442-6335.

Our Physicians

Hossein Ameri, MDAmir Kashani, MD, PhDMark S. Humayun, MD, PhDLinda Lam, MD, MBAThomas C. Lee, MDAndrew Moshfeghi, MD, MBA, Damien Rodger, MD, PhD

Please visit our Doctors page for summaries of the basic/translational and clinical research being conducted by our clinicians.

Next, read about the USC Retinal Degeneration Center.