Fall 2017 Newsletter

Follow our latest updates in our Fall 2017 Newsletter

Fall 2017 Newsletter
7th Residency Announcement

Exciting Residency Announcement!

ACGME approves seventh resident complement; first increase in over 30 years!

Grand Rounds

Grand Rounds and Case Studies

Check out our weekly presentations

OTEP

OTEP

Ophthalmic Technician Education Program

LARGEST STUDY ON CHINESE AMERICANS PUBLISHED

LARGEST STUDY ON CHINESE
AMERICANS PUBLISHED

USC Ophthalmology Researchers Find More
Effective Treatments For Blinding Eye Diseases

EDUCATION

Case Study: You’ve got A Lot Of Nerve

lee patel
Presenter: Ramon Lee, MD Discussant: Vivek Patel, MD
 

History

  • 29-year-old male who presented with 2 weeks of gradual “darkening” of vision simultaneously in both eyes
  • PMH of HIV/AIDS (CD4 94, recently restarted HAART 3 months ago), recurrent cryptococcal meningitis s/p VP shunt, diffuse large B cell lymphoma s/p chemotherapy, and testicular cancer s/p orchiectomy
  • Reports lethargy, but denies nuchal rigidity, photophobia or headache

Exam Findings

  • VA: 20/400, 20/150
  • IOP: 9, 10
  • Pupils: RR OU, + RAPD OD
  • Brightness sense: wnl
  • Red saturation: 50% decreased on OD
  • Color plates: 1/9 OU
  • EOM: full OU
  • SLE: unremarkable
Figure 1
Figure 1: Left eye fundus photo at current presentation shows disc edema, retinal (Paton’s) folds, and peripapillary hemorrhages.

 

Figure 2

Figure 2: T2-FLAIR axial view MRI on left shows marked progression of signal abnormalities in deep parenchyma, compared with more subtle changes noted 3 months prior, pictured on right.

 

T2-FLAIR axial view demonstrates new involvement of the optic tracts (arrows) and surrounding tissues (left image). The right image is T1-post-contrast orbital MRI, axial view showing subtle enhancement of the left > right optic nerve/sheath complex suggesting some degree of inflammation/infection/infiltration.
Figure 3: T2-FLAIR axial view demonstrates new involvement of the optic tracts (arrows) and surrounding tissues (left image). The right image is T1-post-contrast orbital MRI, axial view showing subtle enhancement of the left > right optic nerve/sheath complex suggesting some degree of inflammation/infection/infiltration.

 

Figure 4
Figure 4: IVFA left eye shows disc leakage and inferonasal vascular non-perfusion consistent with a focal BRVO.

Differential Diagnosis

  • Consider papilledema vs. non-papilledematous disc edema
  • If elevated ICP (indicating papilledema), consider infectious etiologies (recurrent cryptococcal meningitis and associated impairment of arachnoid granulations), malignancy (CNS lymphoma, metastasis) or mechanical etiology (VP shunt malfunction)
  • If normal ICP, consider infiltrative optic neuropathy (cryptococcal infiltration, lymphomatous infiltration) or other opportunistic infection (CNS toxoplasmosis, brain abscess, etc.)
  • Also need to keep immune reconstitution inflammatory syndrome (IRIS) and progressive multifocal leukoencephalopathy (PML) on differential

Additional Investigations

  • VP shunt evaluation: no elevation of ICP
  • CSF studies: Cryptococcal antigen 1:160
  • MR spectroscopy: more consistent with infectious rather than malignant etiology

Diagnosis

  • Cryptococcal optic neuropathy/neuritis
  • IRIS producing worsening brain parenchymal involvement with involvement of optic tracts

Pathophysiology

With the determination of normal ICP, it was concluded that the optic neuropathy was most likely related to infiltration  and inflammation of the optic nerves secondary to worsening cryptococcal infection rather than the more commonly seen scenario of papilledema secondary to elevated ICP from cryptococcal meningitis. It is estimated that approximately 75% of patients with cryptococcal meningitis will develop elevation of ICP (often severe) thought to result from the depositing of proteins and inflammatory by-products along the arachnoid granulations. This impairs absorption of CSF. In our case, the hypothesis of worsening cryptococcal infection was supported by the observed increase in enhancing cystic lesions on follow-up brain MRI. There is also likely a component of IRIS given the patient’s history of cryptococcal infection and re-initiation of HAART 3 months prior. The worsening parenchymal edema on MRI is consistent with this heightened inflammatory response.

Treatment

  • High dose oral Prednisone
  • Fluconazole
  • Continued HAART

Prognosis and Future Directions

  • Mainstay of treatment is to continue to treat the presumed underlying infectionwhile attempting to mitigate the immune reconstitution inflammatory response with steroids while continuing HAART
  • Our patient experienced improvement in vision bilaterally, reduction in disc edema and associated hemorrhages with the above treatment
  • Needs close follow-up for potential development of recurrent elevation of ICP
  • If worsening white matter involvement despite adequate anti-microbial control, then PML will need to move up on the differential, potentially requiring brain biopsy

 

Figure 5
Figure 5: Left eye fundus photo 2 weeks after initial presentation shows improvement in disc edema and peripapillary hemorrhages while on anti-fungal treatment and prednisone.

 

References

  • Park BJ et al. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009 Feb 20;23(4):525-30.
  • Desalermos A et al. Update on the epidemiology and management of cryptococcal meningitis. Expert Opin Pharmacother. 2012 Apr;13(6):783-9.
  • Perfect JR. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(3):291.
  • Portelinha J et al. Bilateral optic neuropathy associated with cryptococcal meningitis in an immunocompetent patient. BMJ Case Rep. 2014 Jun 11;2014.
  • Merkler AE et al. Direct Invasion of the Optic Nerves, Chiasm, and Tracts by Cryptococcus neoformans in an Immunocompetent Host. Neurohospitalist. 2015 Oct;5(4):217-22.
  • DeSimone JA et al. Inflammatory reactions in HIV-1-infected persons after initiation of highly active antiretroviral therapy. Ann Intern Med. 2000;133(6):447.
  • French MA et al. Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy. HIV Med. 2000;1(2):107.
  • Khurana RN et al. Ophthalmic manifestations of immune reconstitution inflammatory syndrome associated with Cryptococcus neoformans. Ocul Immunol Inflamm. 2008 Jul-Aug;16(4):185-90.

Contact

 

Produced by: Monica Chavez, John Daniel, Joseph Yim and Dr. Vivek Patel
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