The Craft Laboratory focuses on understanding how the genes expressed in the eye and pineal gland interact with the environment. When these genes are abnormal, the defects may lead to loss of sight and deregulation of the body’s “biological clock.” Dr. Craft’s contributions to vision encompass the identification and deciphering of the molecular mechanisms for maintaining normal vision, including arrestins and phosducin, two essential genes that encode critical regulatory components for shutoff and desensitization in both rod and cone photoreceptor signal cascades.
Dr. Craft has discovered and characterized the critical regulatory elements of the cone arrestin that are necessary and sufficient for use in targeting gene rescue to all cones to restore loss of high acuity vision. Her team is currently evaluating the electroretinography data involving the development of alphaB crystallin peptides with therapeutic potential in animal models of age-related macular degeneration.
- Molecular Neurobiology
- Gene Regulation
- Genetics of Inherited Blindness
- Visual Arrestins
- Photoreceptor G-Protein Coupled Receptor