DoctorsSandy X. Zhang-Nunes, MD

Sandy X. Zhang-Nunes, MD

Title: Assistant Professor of Clinical Ophthalmology and the Director of Oculo-Facial Plastics Services

Department: Ophthalmology

Clinical Specialty: Oculo-Facial Plastics, Orbital and Reconstructive Surgery

Treatment Expertise: Oculofacial Plastic Surgery, Droopy Eyelids, Brow Ptosis, Reconstruction After Moh's Tumor Excision, Thyroid Eye Disease, Orbital Facial, Fractures, Cosmetic Surgery, Laser and Light Therapy, Botox, Fillers

Certification: American Board of Ophthalmology

Languages: English, Mandarin, Shanghainese, Limited Spanish

Location: Los Angeles and Arcadia

Biography and Education


Sandy X. Zhang-Nunes, MD, earned her undergraduate degrees at the Massachusetts Institute of Technology and her medical degree at the Johns Hopkins University School of Medicine. She then completed her ophthalmology residency at Jules Stein Eye Institute UCLA and completed a prestigious two-year American Society of Ophthalmic Plastic Surgery Fellowship based at Ophthalmic Surgeons and Consultants of Ohio in Columbus. Her clinical interests involve eyelid and eyebrow lifting surgeries for both cosmesis and functional reasons (blepharoplasty, ptosis surgery, endoscopic brow lifts), cosmetic lower eyelid, midface and full face surgery, reconstruction after Mohs (tumor) excisions, orbital disease, such as thyroid eye disease, tumors, fractures, eyelid malpositions from aging and congenital anomalies, blepharospasm and hemifacial spasm, cosmetic laser and light therapy, Botox and fillers.

Dr. Zhang-Nunes treats each patient with care, addressing concerns to achieve the most natural and optimal results as possible. She also enjoys teaching, having published numerous articles in peer-reviewed journals and book chapters, as well as lecturing and presenting research nationally and internationally.

Research Interests:

Dr. Zhang-Nunes’s research focuses on patients with thyroid eye disease. She also conducts studies related to imaging of eyelid and orbital structures, comparison of cosmetic neurotoxins, and dissolution rate of various hyaluronic acid gel fillers. Dr. Zhang-Nunes performs blepharoplasty and brow surgery corrections and studies their clinical outcomes.


  • BS, Massachusetts Institute of Technology, Brain and Cognitive Sciences, 2003
  • MD, Johns Hopkins University School of Medicine, 2003-2008


  • Intermountain Medical Center, Salt Lake City, UT, 2008-2009


  • University of California Los Angeles, Jules Stein Eye Institute, 2009-2012


  • ASOPRS Fellowship, Ophthalmic Surgeons & Consultants of OH


Professional society memberships:

  • American Academy of Ophthalmology
  • American Society of Ophthalmic Plastic and Reconstructive Surgery
  • Los Angeles County Medical Association
  • California Academy of Eye Physicians and Surgeons
  • Women in Ophthalmology


  • National Merit Scholar, 1999
  • Discover Card Scholarship, 1999
  • Zonta Club scholarship, 1999
  • National Beta Club scholarship, 1999
  • Olympus Titan Award, 1999
  • MIT Excellent Academic Record, 2002
  • Hans-Lukas Teuber Award for outstanding research and academics in Brain and Cognitive Sciences, 2003
  • Community Connection Award for leadership in Alternative Spring Break, 2003
  • Sigma Xi Honor Society, 2003
  • Phi Beta Kappa Honor Society, 2003
  • American Neurological Association Travel Award, Sarnoff Foundation Research Award, 2005
  • Howard Hughes Medical Research Fellowship Award, 2005


  1. Zhang-Nunes SX, Guo S, Lee D, Chang J, Nguyen A. Safety and Efficacy of an Augmented Intense Pulse Light Protocol for Dry Eye Syndrome and Blepharitis. Photobiomodul Photomed Laser Surg. 2020 Dec 28. doi: 10.1089/photob.2020.4913. Online ahead of print. PubMed PMID: 33370543
  2. Ryu C, Lu JE, Zhang-Nunes SX. Response of twelve different hyaluronic acid gels to varying doses of recombinant human hyaluronidase. J Plast Reconstr Aesthet Surg. 2020 Nov 6:S1748-6815(20)30548-9. Online ahead of print. PubMed PMID: 33308988.
  3. Zhang-Nunes SX, Ryu C, Cahill K, Straka D, Nabavi C, Czyz C, Foster J. Prospective in vivo evaluation of three different hyaluronic acid gels to varying doses of hyaluronidase with long-term follow-up. J Plast Reconstr Aesthet Surg. 2020 Nov 6:S1748-6815(20)30549-0. Online ahead of print. PubMed PMID: 33281083
  4. Kalasho BD, Minokadeh A, Zhang-Nunes SX, Zoumalan RA, Shemirani NL, Waldman AR, Pletzer V, Zoumalan CI. Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study. J Cosmet Sci. 2020 Sep/Oct;71(5):263-290. PubMed PMID: 33022197.
  5. Tran AQ, Zhang-Nunes SX, Cahill K, Alabiad CR, Shriver EM, Ho T, Weinberg DA, Couch SM, Schlachter DM, Nguyen J, Weste. Thyroid eye disease with choroidal folds. Orbit. 2020 Apr 23:1-9. doi: 10.1080/01676830.2020.1756347. Online ahead of print. PubMed PMID: 32326785
  6. Lu JE, Chang JR, Berry JL, In GK, Zhang-Nunes S. Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma. Int Ophthalmol Clin. 2020 Spring;60(2):77-89. PubMed PMID: 32205655
  7. Ting MYL, Shan M, Gantz O, Zhang-Nunes S, Wrobel B. Optic Neuropathy due to an Ethmoid Mucocele: A Case Report and Literature Review. Case Rep Ophthalmol. 2019 Aug 6;10(2):227-234. PubMed PMID: 31692625
  8. Wu Y, Seong YJ, Li K, Choi D, Park E, Daghlian GH, Jung E, Bui K, Zhao L, Madhavan S, Daghlian S, Daghlian P, Chin D, Cho IT, Wong AK, Heur M, Zhang-Nunes SX, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. 2020 Jul 9;5(13):e135121. doi: 10.1172/jci.insight.135121. PubMed PMID: 32641580.
  9. Zhang-Nunes SX, Dang S, Garneau HC, Hwang C, Isaacs D, Chang SH, et al. Characterization and outcomes of repeat orbital decompression for thyroid-associated orbitopathy. Orbit (Amsterdam, Netherlands). 2015;34(2):57-65. Epub 2014/09/23. doi: 10.3109/01676830.2014.949784. PubMed PMID: 25244551.
  10. Hill RH, 3rd, Czyz CN, Kandapalli S, Zhang-Nunes SX, Cahill KV, Wulc AE, et al. Evolving Minimally Invasive Techniques for Tear Trough Enhancement. Ophthalmic plastic and reconstructive surgery. 2015;31(4):306-9. Epub 2014/10/10. doi: 10.1097/iop.0000000000000325. PubMed PMID: 25299740.
  11. Briceno CA, Zhang-Nunes SX, Massry GG. Minimally invasive surgical adjuncts to upper blepharoplasty. Facial plastic surgery clinics of North America. 2015;23(2):137-51. Epub 2015/04/30. doi: 10.1016/j.fsc.2015.01.013. PubMed PMID: 25921565.
  12. Briceno CA, Zhang-Nunes SX, Massry GG. Minimally invasive options for the brow and upper lid. Facial plastic surgery clinics of North America. 2015;23(2):153-66. Epub 2015/04/30. doi: 10.1016/j.fsc.2015.01.012. PubMed PMID: 25921566.
  13. Liu Y, Zhang-Nunes S, Zhu X, Xu X, Sun X, Wu Y. Late adult onset optic pathway astrocytoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2013;20(11):1610-2. Epub 2013/06/25. doi: 10.1016/j.jocn.2012.09.044. PubMed PMID: 23790623.
  14. Zhang-Nunes SX, Jarullazada I, Mancini R. Late central visual recovery after traumatic globe displacement into the maxillary sinus. Ophthalmic Plast Reconstr Surg. 2012 Jan-Feb;28(1):e17-9. PubMed PMID: 21490518.
  15. Zhang-Nunes SX, Jarullazada I, Mancini R. Late central visual recovery after traumatic globe displacement into the maxillary sinus. Ophthalmic plastic and reconstructive surgery. 2012;28(1):e17-9. Epub 2011/04/15. doi: 10.1097/IOP.0b013e318213f5fb. PubMed PMID: 21490518.
  16. Xu Y, Cai Y, Gong N, Chen C, Wu Y, Zhang-Nunes S, et al. Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1. Biochemical and biophysical research communications. 2007;361(2):499-504. Epub 2007/07/28. doi: 10.1016/j.bbrc.2007.07.042. PubMed PMID: 17655829.
  17. Wu YC, Zhao YB, Tang MG, Zhang-Nunes SX, McArthur JC. AIDS dementia complex in China. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2007;14(1):8-11. Epub 2006/10/31. doi: 10.1016/j.jocn.2005.07.012. PubMed PMID: 17070055.
  18. Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, et al. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(8):1973-80. Epub 2007/02/23. doi: 10.1523/jneurosci.5426-06.2007. PubMed PMID: 17314293.
  19. Kinkingnehun S, Volle E, Zhang-Nunes SX, Pelegrini-Issac M, Golmard JL, Lehericy S, du Boisgueheneuc F, et al. A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): method and validation. NeuroImage. 2007;37(4):1237-49. Epub 2007/08/19. doi: 10.1016/j.neuroimage.2007.06.027. PubMed PMID: 17702605.
  20. Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain pathology (Zurich, Switzerland). 2006;16(1):30-9. Epub 2006/04/15. PubMed PMID: 16612980.
  21. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of disease. 2006;24(3):516-24. Epub 2006/10/13. doi: 10.1016/j.nbd.2006.08.017. PubMed PMID: 17029828.
  22. du Boisgueheneuc F, Levy R, Volle E, Zhang-Nunes SX, Seassau M, Duffau H, Kinkingnehun S, et al. Functions of the left superior frontal gyrus in humans: a lesion study. Brain : a journal of neurology. 2006;129(Pt 12):3315-28. Epub 2006/09/21. doi: 10.1093/brain/awl244. PubMed PMID: 16984899.
  23. Arjona AA, Zhang SX, Adamson B, Wurtman RJ. An animal model of antipsychotic-induced weight gain. Behavioural brain research. 2004;152(1):121-7. Epub 2004/05/12. doi: 10.1016/j.bbr.2003.09.040. PubMed PMID: 15135975.