DoctorsHardeep Pal Singh, PhD

Hardeep Pal Singh, PhD

Hardeep Pal Singh, PhD

Title: Assistant Professor of Research Ophthalmology

Department: Ophthalmology

Location: Children's Hospital Los Angeles

Research Topics:

Retinoblastoma
Retinal Development
Retinal Dystrophies

Biography and Education

Research Interests:

Hardeep Singh, PhD, studies retinoblastoma development. His research is focused on understanding how features of the cone cell of origin of retinoblastoma sensitize to RB loss and MYCN over-expression to enable cone precursor proliferation. He particularly aims to understand a human cone precursor proliferation related program as a step towards producing humanized mouse models that better mimic human cone and retinoblastoma biology.

Education:

  • University of Alberta, Memorial Sloan Kettering Cancer Center, Children’s Hospital Los Angeles, Post-Doctoral Fellowship
  • L. V. Prasad Eye Institute, Hyderabad, India, PhD (Genetics of Retinal Dystrophies), 2010
  • Guru Nanak Dev University, Amritsar, India, MSc (Human Genetics), 2002
  • DAV College, Jalandhar, India, BSc (Biology, Chemistry), 2000

Accomplishments

Awards:

  • The Saban Research Institute (TSRI), Travel Award, 2019
  • Association for Research in Vision and Ophthalmology (ARVO), Travel Award, 2018
  • International Society for Eye Research (ISER), Travel Award, 2016
  • Indian Eye Research Group (IERG), Travel Award, 2008
  • Council of Scientific and Industrial Research (CSIR), Senior Research Fellow, 2007

Publications:

  1. Li, Z, DL Qui, HP Singh, Y Zou, B Shen, D Cobrinik. A novel thyroid hormone receptor isoform, TRβ2 46, promotes SKP2 expression and retinoblastoma cell proliferation. J Biol Chem, 2019.
  2. HP Singh, S Wang, K Stachelek, S Lee, MW Reid, ME Thornton, CM Craft, BH Grubbs, and D Cobrinik. Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci (USA) 115:E9391-E9400. 2018. PMID: 30213853.
  3. Xu XL, HP Singh, L Wang, D Qi, B Poulos, D Abramson, S Jhanwar, and D Cobrinik. 2014. Rb suppresses human cone precursor-derived retinoblastoma tumours. Nature 514:385-388. 2014. PMCID: PMC4232224.
  4. Kannabiran C, HP Singh, N Sahini, S Jalali, G Mohan 2012. Mutations in TULP1, NR2E3, and MFRP genes in Indian families with autosomal recessive retinitis pigmentosa. Mol Vis 18:1165-1174. 2012. PMID: 22605927 PMCID: PMC3351411.
  5. Seo S, HP Singh, PM Lacal, A Sasman, A Fatima, T Liu, KM Shinnick, DW Losordo, OJ Lehmann, and T Kume. 2012. FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci (USA) 109:2015-2020. 2012. PMCID: PMC3277512.
  6. Kannabiran C, HP Singh, and S Jalali. Mapping of locus for autosomal dominant retinitis pigmentosa on chromosome 6q23. Hum Genet 131:717-723. 2011. PMID: 22083234.
  7. HP Singh, S Jalali, and C Kannabiran. Genetic analysis of Indian families with autosomal recessive retinitis pigmentosa by homozygosity screening. Invest Ophthalmol and Vis Sci 50:4065-4071. 2009 PMCID: PMC2777646.
  8. Friedman JS, B Chang, C Kannabiran, C Chakarova, HP Singh, S Jalali, NL.Hawes, K Branham, M Othman, E Filippova, DA Thompson, A Webster, S Andréasson, SG Jacobson, SS Bhattacharya, JR Heckenlively, and A Swaroop. Premature truncation of a novel protein, RD3, exhibiting sub-nuclear localization is associated with retinal degeneration. Am J Hum Genet 79:1059-1070. 2006 PMCID: PMC1698706.