Hamm-Alvarez Laboratory Recent Publications

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Recent Publications

  1. Lee C, Guo H, Klinngam W, Janga SR, Yarber F, Peddi S, Edman MC, Tiwari N, Liu S, Louie SG, Hamm-Alvarez SF, MacKay JA. Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. Mol Pharm. 2019 May 30. doi: 10.1021/acs.molpharmaceut.9b00263. [Epub ahead of print]
  2. Janga SR, Hamm-Alvarez SF. PP2A: A Novel Target to Prevent Cathepsin S-Mediated Damage in Smoking-Induced COPD. Am J Respir Crit Care Med. 2019 Feb 20. doi: 10.1164/rccm.201901-0219ED. [Epub ahead of print]
  3. Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA. A Novel Elastin-like Polypeptide Drug Carrier for Cyclosporine A Improves Tear Flow in a Mouse Model of Sjögren’s Syndrome. J Control Release. 2018 Dec 28;292:183-195.
  4. Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF. Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells. Int J Mol Sci. 2018 Nov 9;19(11).
  5. Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF. NOD and NOR Mice Exhibit Comparable Development of Lacrimal Gland Secretory Dysfunction but NOD Mice Have More Severe Autoimmune Dacryoadenitis. Exp Eye Res. 2018 Nov;176:243-251.
  6. Janga SR, Shah M, Ju Y, Meng Z, Edman MC, Hamm-Alvarez SF. Longitudinal Analysis of Tear Cathepsin S Activity Levels in Male Non-Obese Diabetic Mice Suggests its Potential as an Early Stage Biomarker of Sjögren’s Syndrome. Biomarkers. 2018 Sep 12:1-12. [Epub ahead of print]
  7. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF. Increased Cathepsin S Activity Associated with Decreased Protease Inhibitory Capacity Contributes to Altered Tear Proteins in Sjögren’s Syndrome Patients. Sci Rep. 2018 Jul 23;8(1):11044.
  8. Hawley D, Tang X, Zyrianova T, Shah M, Janga S, Letourneau A, Schicht M, Paulsen F, Hamm-Alvarez S, Makarenkova HP, Zoukhri D. Myoepithelial Cell-Driven Acini Contraction in Response to Oxytocin Receptor Stimulation is Impaired in Lacrimal Glands of Sjögren’s Syndrome Animal Models. Sci Rep. 2018 Jul 2;8(1):9919.
  9. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjogren’s Syndrome. Stem Cells Int. 2017 Mar;2017:3134543.
  10. Meng Z, Klinngam W, Edman MC, Hamm-Alvarez SF. Interferon-γ Treatment in vitro Elicits Some of the Changes in Cathepsin S and Antigen Presentation Characteristic of Lacrimal Glands and Corneas from the NOD Mouse Model of Sjögren’s Syndrome. PLoS One. 2017 Sep 13;12(9):e0184781.
  11. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation in a Murine Model of Sjogren’s Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan;58(1):372-85.
  12. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 Increases Cathepsin S Secretion from Lacrimal Acini in a Mouse Model of Sjögren’s Syndrome. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C942-54.
  13. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. Elastin-like Polypeptides: Therapeutic Applications for an Emerging Class of Nanomedicines. J Control Release. 2016 Oct 28;240:93-108.
  14. Hamm-Alvarez SF, Janga SR, Edman-Woolcott MC, Madrigal S, Shah M, Frousiakis S, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DA, Irvine J, Mack W, Stohl W. Tear Cathepsin S-A Candidate Biomarker for Sjögren’s Syndrome. Arthritis Rheumatol 66: 1872-1881, 2014.
  15. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, MacKay JA, Hamm-Alvarez SF. A Rapamycin-Binding Protein Polymer Nanoparticle Shows Potent Therapeutic Activity in Suppressing Autoimmune Dacryoadenitis in a Mouse Model of Sjögren’s Syndrome. J Cont Rel 171: 269-279, 2013.
  16. Li X, Wu K, Edman M, Schenke-Layland, MacVeigh-Aloni M, Janga S, Schulz B, Hamm-Alvarez SF. Increased Expression of Cathepsins and Obesity-Induced Pro-Inflammatory Cytokines in Lacrimal Glands of Male NOD Mouse. IOVS 51:5019-5029, 2010.